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Working & Treatment of Fluconazole
- Diflucan |
Diflucan is the branded medicine manufactured and distributed by
Pfizer Inc of the United States, having Fluconazole as the active
pharmaceutical ingredient which is meant for treating different
fungal infections like Candidiasis. Such fungal infections usually
incorporate infections of vagina, throat, urinary tract, peritonitis
and pneumonia in general. The drug is also found being prescribed by
the doctors for treating the patients undergoing bone marrow
transplants, treating the patients with meningitis caused by certain
type of fungus. In the modern times, Diflucan-Fluconazole is also
widely prescribed for treating the patients with fungal infection in
their kidneys or for the patients undergoing liver transplant
surgeries and the most surprisingly for the patients having AIDS.
Diflucan-Fluconazole is the highly selective inhibitor of fungal
cytochrome P-450 sterol C-14 alpha-demethylation which is the
mammalian cell much less sensitive to Fluconazole inhibition. The
consequent loss of normal sterols associates with the accretion of
14 alpha-methyl sterols in fungi and may be liable for the
fungi-static actions of Diflucan-Fluconazole. The medicine should be
taken strictly as prescribed by the physician and no dose should
ever be deviated unless otherwise referred by the doctor.
Diflucan-Fluconazole is indicated for the treatment of vaginal
candidiasis or vaginal yeast infection due to Candida, oropharyngeal
and esophageal candidiasis. It is also effective for the treatment
of Candida urinary tract infections, systemic Candida infections
including Candidemia, disseminated Candidiasis and pneumonia.
However, the doctor may insist on specimens for fungal culture and
other relevant laboratory studies like serology, histopathology
before instituting the Diflucan-Fluconazole therapy for isolating
and identifying causative organisms.
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